Compound Summary
Compound Information
SB 224289 hydrochloride
Compound Name: | SB 224289 hydrochloride |
Compound CID: | 11226716 |
Synonyms: | SB 224289 hydrochloride SB-224289 hydrochloride 180084-26-8 SB-224289A UNII-RTX59ZSB74 More... |
Iupac Name: | [4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone;hydrochloride |
InChI: | InChI=1S/C32H32N4O3.ClH/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32;/h4-9,16-18H,10-15,19H2,1-3H3;1H |
InChIKey: | GKGKBZYMDILCOF-UHFFFAOYSA-N |
Canonical Smiles: | CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl |
Isomeric Smiles: | CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl |
Molecular Weight: | 557.1 |
Molecular Formula: | C32H33ClN4O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
SB 224289 hydrochloride
Molecular Weight: | 557.1 |
Molecular Formula: | C32H33ClN4O3 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 3 |
Heavy Atom Count: | 40 |
Complexity: | 885 |
Synonyms
SB 224289 hydrochloride
| SB 224289 hydrochloride | SB 224289 hydrochloride |
|---|---|
SB 224289 hydrochloride |
SB-224289 hydrochloride |
180084-26-8 |
SB-224289A |
UNII-RTX59ZSB74 |
SB 224289 HCl |
sb224289 hydrochloride |
SB 224289A |
RTX59ZSB74 |
CHEBI:64067 |
4-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenylphenyl-(1-methylspiro6,7-dihydro-2H-furo2,3-findole-3,4-piperidine-5-yl)methanone;hydrochloride" |
(1-methyl-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidin-5-yl)2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylmethanone hydrochloride" |
(2-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-yl)(1-methyl-6,7-dihydrospirofuro2,3-findole-3,4-piperidin-5(2H)-yl)methanone hydrochloride" |
1-methyl-5-{2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl}-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidinium chloride |
SMR001254111 |
SR-01000075552 |
1-METHYL-5-2-METHYL-4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YLCARBONYL-2,3,6,7-TETRAHYDROSPIROFURO2,3-FINDOLE-3,4-PIPERIDINE HYDROCHLORIDE |
EU-0101173 |
MLS002172488 |
MLS006010774 |
C32H32N4O3.HCl |
SCHEMBL6926494 |
SB 224289 (hydrochloride) |
SB224289 HCl |
CHEMBL1256869 |
DTXSID9042627 |
AOB1765 |
BCP27864 |
AKOS024427780 |
CS-7876 |
HY-101105A |
MCULE-1380259298 |
NCGC00094430-01 |
1-Methyl-5-2-methyl-4-(5-methyl-1 ,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl-2,3,6, 7-tetrahydrospirofuro2,3-findole-3,4-piperidine hydrochloride |
AC-27413 |
AS-16681 |
Methanone, (2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)(2,5,6,7-tetrahydro-1-methylspiro(3H-furo(2,3-f)indole-3,4-piperidin)-5-yl)-, hydrochloride (1:1)" |
Spiro(2H-furo(2,3-f)indole-3(5H),4-piperidine), 6,7-dihydro-1-methyl-5-((2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)carbonyl)-, monohydrochloride |
B6641 |
S-201 |
J-011498 |
J-011499 |
SR-01000075552-1 |
SR-01000075552-3 |
Q27133002 |
SB-224289A;SB-224289 hydrochloride; SB 224289 hydrochloride |
1-Methyl-5-(2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl carbonyl)-2,3,6,7-tetrahydro-spiro(furo2,3-findole-3,4-piperidine)" |
1-Methyl-5-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl-2,3,6,7-tetrahydrospirofuro2,3-findole-3,4-piperidine hydrochloride" |
1-methyl-5-{2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl}-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidine hydrochloride" |
Experimental Data
SB 224289 hydrochloride
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 4 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
SB 224289 hydrochloride
Statistics Data
SB 224289 hydrochloride
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 4 | 1 | 1 |
Statistics Data Visualization
SB 224289 hydrochloride
