Compound Summary
6-bromoindirubin-3\'-oxime
Compound Information
6-bromoindirubin-3'-oxime
Compound Name: | 6-bromoindirubin-3'-oxime |
Compound CID: | 448949 |
Synonyms: | 667463-62-9 BIO 6-BROMOINDIRUBIN-3-OXIME GSK-3 Inhibitor IX 6BIO More... |
Iupac Name: | 6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol |
InChI: | InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H |
InChIKey: | SAQUSDSPQYQNBG-UHFFFAOYSA-N |
Canonical Smiles: | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O |
Isomeric Smiles: | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O |
Molecular Weight: | 356.17 |
Molecular Formula: | C16H10BrN3O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
6-bromoindirubin-3'-oxime
Molecular Weight: | 356.17 |
Molecular Formula: | C16H10BrN3O2 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 22 |
Complexity: | 438 |
Synonyms
6-bromoindirubin-3'-oxime
| 6-bromoindirubin-3'-oxime | 6-bromoindirubin-3'-oxime |
|---|---|
667463-62-9 |
BIO |
6-BROMOINDIRUBIN-3-OXIME |
GSK-3 Inhibitor IX |
6BIO |
6-bromoindirubin-3-oxime |
6-BIO |
GSK 3 Inhibitor IX |
(2Z,3E)-6-Bromoindirubin-3-oxime |
GSK 3B Inhibitor IX |
(2Z,3E)-6-Bromoindirubin-3-oxime |
GSK 3 IX |
C16H10BrN3O2 |
CHEMBL243555 |
CHEBI:86290 |
MLS 2052 |
MLS-2052 |
(2Z,3E)-6-Bromo-3-(hydroxyimino)-2,3-biindolinylidene-2-one" |
(3E)-6-BROMO-2,3-BIINDOLE-2,3(1H,1H)-DIONE 3-OXIME |
710323-58-3 |
BRW |
(2E,3E)-6-bromo-3-(hydroxyimino)-2,3-biindolinylidene-2-one" |
(2Z,3E)-6-bromo-2,3-biindole-2,3(1H,1H)-dione 3-oxime |
6BIO cpd |
GSK-3 Inhibitor IX (BIO) |
MFCD08705318 |
GSK-3-inhibitor-IX |
1uv5 |
6-bromo-indirubin-3oxime |
BIO; 6-BIO |
6-bromoindirubin-3-oxime |
MLS001074886 |
SCHEMBL470802 |
CHEMBL355496 |
GTPL5974 |
SCHEMBL4997980 |
SCHEMBL8246737 |
6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol |
CHEMBL2178734 |
SCHEMBL14088703 |
SCHEMBL15565919 |
SCHEMBL21067440 |
SCHEMBL23042946 |
CHEBI:91343 |
DTXSID60648023 |
EX-A689 |
HMS2230G20 |
HMS3229G18 |
HMS3262K08 |
HMS3265E19 |
HMS3265E20 |
HMS3265F19 |
HMS3265F20 |
HMS3374K01 |
HMS3413H16 |
HMS3648C22 |
HMS3653G17 |
HMS3677H16 |
BCP07234 |
BIO, >=98% (HPLC) |
Tox21_500773 |
(3Z)-6-bromo-3-3-(hydroxyamino)indol-2-ylidene-1H-indol-2-one |
BDBM50012188 |
BDBM50191406 |
BDBM50526697 |
HB1259 |
HSCI1_000232 |
NSC737347 |
NSC745931 |
s7198 |
ZINC18128386 |
ZINC18128389 |
AKOS024457468 |
AKOS026750263 |
AKOS030238964 |
AKOS032947350 |
ZINC100469404 |
ZINC100493712 |
CCG-101292 |
CCG-208082 |
CS-3360 |
DB03444 |
LP00773 |
NSC-737347 |
NSC-745931 |
SDCCGSBI-0633754.P001 |
NCGC00094112-01 |
NCGC00094112-02 |
NCGC00094112-03 |
NCGC00094112-04 |
NCGC00094112-06 |
NCGC00094112-15 |
NCGC00261458-01 |
AC-32731 |
AS-55790 |
BB162775 |
DA-33591 |
HY-10580 |
SMR000568408 |
B4006 |
SW219792-1 |
K00001 |
MLS-0388607.0001 |
W13430 |
EN300-1692898 |
GSK-3 Inhibitor IX - CAS 667463-62-9 |
A867399 |
SR-01000838093 |
6BIO;GSK 3 IX;GSK 3 Inhibitor IX;MLS 2052 |
SR-01000838093-3 |
Q27077902 |
Q27094369 |
Q27163220 |
Z199053426 |
6-bromo-3-3-(hydroxyamino) indol-2-ylidene-1h-indol-2-one |
6-bromo-3-3-(hydroxyamino)-2-indolylidene-1H-indol-2-one |
(Z)-6-Bromo-1H,1H-2,3biindolylidene-3,2-dione 3-oxime |
(3Z)-6-bromo-3-(3E)-3-hydroxyiminoindolin-2-ylideneindolin-2-one |
(Z)-6-Bromo-1H,1H-2,3biindolylidene-3,2-dione 3-oxime" |
(Z,3E)-6-bromo-3-(hydroxyimino)-1,2-dihydro-1H,3H-2,3-biindolyliden-2-one |
6-Bromo-3-3-(hydroxyamino)-2H-indol-2-ylidene-1,3-dihydro-2H-indol-2-one |
6-bromo-3-3-(hydroxyamino)-2H-indol-2-ylidene-2,3-dihydro-1H-indol-2-one |
6-Bromo-3-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene-1,3-dihydro-2H-indol-2-one |
(3Z)-6-bromo-3-(3E)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene-1,3-dihydro-2H-indol-2-one |
2H-Indol-2-one,6-bromo-3-(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene-1,3-dihydro-,(3Z)- |
6-bromo-3-(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene-1,3-dihydro-(3Z)-2H-indol-2-one |
Experimental Data
6-bromoindirubin-3'-oxime
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 200.000000000000000 | umol/L | 35.000000000000000 | 42.000000000000000 | 20.000000000000000 | 57.000000000000000 | 60.000000000000000 | 0.050000000000000 | S | w1118 | 28253732 | Active | |
| Drosophila melanogaster | 100.000000000000000 | umol/L | 35.000000000000000 | 38.000000000000000 | 8.570000000000000 | 57.000000000000000 | 52.000000000000000 | -0.090000000000000 | NS | w1118 | 28253732 | Inactive | |
| Drosophila melanogaster | 400.000000000000000 | umol/L | 40.000000000000000 | 48.000000000000000 | 20.000000000000000 | 67.000000000000000 | 71.000000000000000 | 0.060000000000000 | S | w1118 | 28253732 | Active | |
| Drosophila melanogaster | 400.000000000000000 | umol/L | 35.000000000000000 | 45.000000000000000 | 28.570000000000000 | 57.000000000000000 | 64.000000000000000 | 0.120000000000000 | S | w1118 | 28253732 | Active |
Experimental Data Visualization
6-bromoindirubin-3'-oxime
Statistics Data
6-bromoindirubin-3'-oxime
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 28.570000000000000 | 0.120000000000000 | 1 | 4 |
Statistics Data Visualization
6-bromoindirubin-3'-oxime
