Compound Summary
GSK690693
Compound Information
GSK690693
Compound Name: | GSK690693 |
Compound CID: | 16725726 |
Synonyms: | 937174-76-0 GSK690693 GSK-690693 GSK 690693 (S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo4,5-cpyridin-4-yl)-2-methylbut-3-yn-2-ol More... |
Iupac Name: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[[(3S)-piperidin-3-yl]methoxy]imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol |
InChI: | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27)/t13-/m0/s1 |
InChIKey: | KGPGFQWBCSZGEL-ZDUSSCGKSA-N |
Canonical Smiles: | CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
Isomeric Smiles: | CCN1C2=C(C(=NC=C2OC[C@H]3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
Molecular Weight: | 425.5 |
Molecular Formula: | C21H27N7O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
GSK690693
Molecular Weight: | 425.5 |
Molecular Formula: | C21H27N7O3 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 9 |
Rotatable Bond Count: | 7 |
Heavy Atom Count: | 31 |
Complexity: | 680 |
Synonyms
GSK690693
| GSK690693 | GSK690693 |
|---|---|
937174-76-0 |
GSK690693 |
GSK-690693 |
GSK 690693 |
(S)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-ylmethoxy)-1H-imidazo4,5-cpyridin-4-yl)-2-methylbut-3-yn-2-ol |
4-2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3S)-3-piperidinylmethoxy-1H-imidazo4,5-cpyridin-4-yl-2-methyl-3-butyn-2-ol |
pan-Akt inhibitor GS690693 |
CHEBI:90677 |
GWH480321B |
4-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3S)-piperidin-3-ylmethoxyimidazo4,5-cpyridin-4-yl-2-methylbut-3-yn-2-ol |
(R)-4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-(PIPERIDIN-3-YLMETHOXY)-1H-IMIDAZO4,5-CPYRIDIN-4-YL)-2-METHYLBUT-3-YN-2-OL |
4-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3S)-piperidin-3-ylmethoxy-1H-imidazo4,5-cpyridin-4-yl-2-methylbut-3-yn-2-ol |
4-{2-(4-Amino-1,2,5-Oxadiazol-3-Yl)-1-Ethyl-7-(3s)-Piperidin-3-Ylmethoxy-1h-Imidazo4,5-Cpyridin-4-Yl}-2-Methylbut-3-Yn-2-Ol |
UNII-GWH480321B |
4-2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(3S)-3-piperidinylmethoxy)-1H-imidazo4,5-cpyridin-4-yl-2-methyl-3-butyn-2-ol |
G93 |
compound 3g PMID 18800763 |
SCHEMBL310452 |
CHEMBL494089 |
GTPL5196 |
BDBM25013 |
DTXSID60239551 |
EX-A031 |
BCP01721 |
MFCD18711681 |
NSC766991 |
NSC800766 |
s1113 |
ZINC34285211 |
AKOS015904356 |
AT18727 |
BCP9000745 |
CCG-264825 |
DB12745 |
NSC-766991 |
NSC-800766 |
NCGC00263181-01 |
AC-23166 |
AS-16204 |
BG174974 |
HY-10249 |
GSK690693,GSK-690693 |
SW218127-2 |
GSK690693, >=98% (HPLC) |
A25176 |
174G760 |
J-502225 |
Q27077916 |
(-)-4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-((3S)-3-PIPERIDINYLMETHOXY)-1H-IMIDAZO(4,5-C)PYRIDIN-4-YL)-2-METHYL-3-BUTYN-2-OL |
(R)-4-(2-(4-Amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-(piperidin-3-yl-MeO)-1H-imidazo4,5-cpyridin-4-yl)-2-Me-but-3-yn-2-ol |
3-BUTYN-2-OL, 4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-((3S)-3-PIPERIDINYLMETHOXY)-1H-IMIDAZO(4,5-C)PYRIDIN-4-YL)-2-METHYL- |
4-(2-(4-AMINO-1,2,5-OXADIAZOL-3-YL)-1-ETHYL-7-((3S)-3-PIPERIDINYLMETHOXY)-1H-IMIDAZO(4,5-C)PYRIDIN-4-YL)-2-METHYL-3-BUTYN-2-OL, (-)- |
4-2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{(3S)-piperidin-3-ylmethoxy}-1H-imidazo4,5-cpyridin-4-yl-2-methylbut-3-yn-2-ol |
Experimental Data
GSK690693
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 10.000000000000000 | umol/L | NS | WDah | FEMALES | 35065134 | Inactive | ||||||
| Drosophila melanogaster | 5.000000000000000 | umol/L | 61.400000000000000 | 66.600000000000000 | 8.500000000000000 | S | WDah | FEMALES | 35065134 | Active | |||
| Drosophila melanogaster | 1.000000000000000 | umol/L | NS | WDah | FEMALES | 35065134 | Inactive |
Experimental Data Visualization
GSK690693
Statistics Data
GSK690693
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 8.500000000000000 | 1 | 3 |
Statistics Data Visualization
GSK690693
