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Compound Summary

SB 224289 hydrochloride

Compound Information

SB 224289 hydrochloride

Compound Name:	SB 224289 hydrochloride
Compound CID:	11226716
Synonyms:	SB 224289 hydrochloride SB-224289 hydrochloride 180084-26-8 SB-224289A UNII-RTX59ZSB74 More...
Iupac Name:	[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone;hydrochloride
InChI:	InChI=1S/C32H32N4O3.ClH/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32;/h4-9,16-18H,10-15,19H2,1-3H3;1H
InChIKey:	GKGKBZYMDILCOF-UHFFFAOYSA-N
Canonical Smiles:	CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl
Isomeric Smiles:	CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl
Molecular Weight:	557.1
Molecular Formula:	C32H33ClN4O3

Compound Structure

2D Structure:

3D Structure:

Computed Properties

SB 224289 hydrochloride

Molecular Weight:	557.1
Molecular Formula:	C32H33ClN4O3
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	6
Rotatable Bond Count:	3
Heavy Atom Count:	40
Complexity:	885

Synonyms

SB 224289 hydrochloride

SB 224289 hydrochloride	SB 224289 hydrochloride
SB 224289 hydrochloride	SB-224289 hydrochloride
180084-26-8	SB-224289A
UNII-RTX59ZSB74	SB 224289 HCl
sb224289 hydrochloride	SB 224289A
RTX59ZSB74	CHEBI:64067
4-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenylphenyl-(1-methylspiro6,7-dihydro-2H-furo2,3-findole-3,4-piperidine-5-yl)methanone;hydrochloride"	(1-methyl-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidin-5-yl)2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylmethanone hydrochloride"
(2-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-yl)(1-methyl-6,7-dihydrospirofuro2,3-findole-3,4-piperidin-5(2H)-yl)methanone hydrochloride"	1-methyl-5-{2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl}-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidinium chloride
SMR001254111	SR-01000075552
1-METHYL-5-2-METHYL-4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YLCARBONYL-2,3,6,7-TETRAHYDROSPIROFURO2,3-FINDOLE-3,4-PIPERIDINE HYDROCHLORIDE	EU-0101173
MLS002172488	MLS006010774
C32H32N4O3.HCl	SCHEMBL6926494
SB 224289 (hydrochloride)	SB224289 HCl
CHEMBL1256869	DTXSID9042627
AOB1765	BCP27864
AKOS024427780	CS-7876
HY-101105A	MCULE-1380259298
NCGC00094430-01	1-Methyl-5-2-methyl-4-(5-methyl-1 ,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl-2,3,6, 7-tetrahydrospirofuro2,3-findole-3,4-piperidine hydrochloride
AC-27413	AS-16681
Methanone, (2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)(2,5,6,7-tetrahydro-1-methylspiro(3H-furo(2,3-f)indole-3,4-piperidin)-5-yl)-, hydrochloride (1:1)"	Spiro(2H-furo(2,3-f)indole-3(5H),4-piperidine), 6,7-dihydro-1-methyl-5-((2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)carbonyl)-, monohydrochloride
B6641	S-201
J-011498	J-011499
SR-01000075552-1	SR-01000075552-3
Q27133002	SB-224289A;SB-224289 hydrochloride; SB 224289 hydrochloride
1-Methyl-5-(2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl carbonyl)-2,3,6,7-tetrahydro-spiro(furo2,3-findole-3,4-piperidine)"	1-Methyl-5-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl-2,3,6,7-tetrahydrospirofuro2,3-findole-3,4-piperidine hydrochloride"
1-methyl-5-{2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl}-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidine hydrochloride"

Experimental Data

SB 224289 hydrochloride

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			4.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

SB 224289 hydrochloride

Statistics Data

SB 224289 hydrochloride

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	4.000000000000000		1	1

Statistics Data Visualization

SB 224289 hydrochloride

Compound Name:

SB 224289 hydrochloride

Compound CID:

11226716

Synonyms:

SB 224289 hydrochloride SB-224289 hydrochloride 180084-26-8 SB-224289A UNII-RTX59ZSB74 More...

Iupac Name:

[4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-(1'-methylspiro[6,7-dihydro-2H-furo[2,3-f]indole-3,4'-piperidine]-5-yl)methanone;hydrochloride

InChI:

InChI=1S/C32H32N4O3.ClH/c1-20-16-25(30-33-21(2)39-34-30)8-9-26(20)22-4-6-23(7-5-22)31(37)36-13-10-24-17-29-27(18-28(24)36)32(19-38-29)11-14-35(3)15-12-32;/h4-9,16-18H,10-15,19H2,1-3H3;1H

InChIKey:

GKGKBZYMDILCOF-UHFFFAOYSA-N

Canonical Smiles:

CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl

Isomeric Smiles:

CC1=C(C=CC(=C1)C2=NOC(=N2)C)C3=CC=C(C=C3)C(=O)N4CCC5=CC6=C(C=C54)C7(CCN(CC7)C)CO6.Cl

Molecular Weight:

557.1

Molecular Formula:

C32H33ClN4O3

Molecular Weight:

557.1

Molecular Formula:

C32H33ClN4O3

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

6

Rotatable Bond Count:

3

Heavy Atom Count:

40

Complexity:

885

SB 224289 hydrochloride

SB-224289 hydrochloride

180084-26-8

SB-224289A

UNII-RTX59ZSB74

SB 224289 HCl

sb224289 hydrochloride

SB 224289A

RTX59ZSB74

CHEBI:64067

4-2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenylphenyl-(1-methylspiro6,7-dihydro-2H-furo2,3-findole-3,4-piperidine-5-yl)methanone;hydrochloride"

(1-methyl-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidin-5-yl)2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylmethanone hydrochloride"

(2-Methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)-1,1-biphenyl-4-yl)(1-methyl-6,7-dihydrospirofuro2,3-findole-3,4-piperidin-5(2H)-yl)methanone hydrochloride"

1-methyl-5-{2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl}-6,7-dihydro-5H-spirofuro2,3-findole-3,4-piperidinium chloride

SMR001254111

SR-01000075552

1-METHYL-5-2-METHYL-4-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YLCARBONYL-2,3,6,7-TETRAHYDROSPIROFURO2,3-FINDOLE-3,4-PIPERIDINE HYDROCHLORIDE

EU-0101173

MLS002172488

MLS006010774

C32H32N4O3.HCl

SCHEMBL6926494

SB 224289 (hydrochloride)

SB224289 HCl

CHEMBL1256869

DTXSID9042627

AOB1765

BCP27864

AKOS024427780

CS-7876

HY-101105A

MCULE-1380259298

NCGC00094430-01

1-Methyl-5-2-methyl-4-(5-methyl-1 ,2,4-oxadiazol-3-yl)biphenyl-4-ylcarbonyl-2,3,6, 7-tetrahydrospirofuro2,3-findole-3,4-piperidine hydrochloride

AC-27413

AS-16681

Methanone, (2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)(2,5,6,7-tetrahydro-1-methylspiro(3H-furo(2,3-f)indole-3,4-piperidin)-5-yl)-, hydrochloride (1:1)"

Spiro(2H-furo(2,3-f)indole-3(5H),4-piperidine), 6,7-dihydro-1-methyl-5-((2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)(1,1-biphenyl)-4-yl)carbonyl)-, monohydrochloride

B6641

S-201

J-011498

J-011499

SR-01000075552-1

SR-01000075552-3

Q27133002

SB-224289A;SB-224289 hydrochloride; SB 224289 hydrochloride

SB 224289 hydrochloride

SB-224289 hydrochloride

180084-26-8

SB-224289A

UNII-RTX59ZSB74

More...