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Compound Summary

minocycline

Compound Information

minocycline

Compound Name:	minocycline
Compound CID:	54675783
Synonyms:	minocycline 10118-90-8 Minocyclin Minociclina Minocyn More...
Iupac Name:	(4S,4aS,5aR,12aR)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
InChI:	InChI=1S/C23H27N3O7/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28/h5-6,9,11,17,27-28,31,33H,7-8H2,1-4H3,(H2,24,32)/t9-,11-,17-,23-/m0/s1
InChIKey:	FFTVPQUHLQBXQZ-KVUCHLLUSA-N
Canonical Smiles:	CN(C)C1C2CC3CC4=C(C=CC(=C4C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Isomeric Smiles:	CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=CC(=C4C(=C3C(=O)[C@@]2(C(=C(C1=O)C(=O)N)O)O)O)O)N(C)C
Molecular Weight:	457.5
Molecular Formula:	C23H27N3O7

Compound Structure

2D Structure:

3D Structure:

Computed Properties

minocycline

Molecular Weight:	457.5
Molecular Formula:	C23H27N3O7
Hydrogen Bond Donor Count:	5
Hydrogen Bond Acceptor Count:	9
Rotatable Bond Count:	3
Heavy Atom Count:	33
Complexity:	971

Synonyms

minocycline

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minocycline	minocycline
(2E,4S,4aR,5aS,12aR)-2-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3 ,12-trione	(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-
(4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE	Tri-minocycline
(4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide	NSC141993

Showing 1 to 3 of 73 entries

Experimental Data

minocycline

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Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	100.000000000000000	umol/L	27.500000000000000	37.300000000000000	36.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	2.000000000000000	umol/L	27.000000000000000	25.800000000000000	-5.000000000000000				NS	N2		30479271	Inactive
Caenorhabditis elegans	50.000000000000000	umol/L	21.600000000000000	31.000000000000000	43.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	200.000000000000000	umol/L	27.000000000000000	30.800000000000000	14.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	2.000000000000000	umol/L	21.700000000000000	21.900000000000000	1.000000000000000				NS	N2		30479271	Inactive
Caenorhabditis elegans	200.000000000000000	umol/L	21.600000000000000	23.800000000000000	10.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	50.000000000000000	umol/L	27.500000000000000	29.000000000000000	5.000000000000000				NS	N2		30479271	Inactive
Caenorhabditis elegans	100.000000000000000	umol/L	23.800000000000000	31.700000000000000	33.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	200.000000000000000	umol/L	27.500000000000000	39.400000000000000	43.000000000000000				S	N2		30479271	Active
Caenorhabditis elegans	100.000000000000000	umol/L	21.600000000000000	32.400000000000000	51.000000000000000				S	N2		30479271	Active

Showing 1 to 10 of 37 entries

Experimental Data Visualization

minocycline

Statistics Data

minocycline

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Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	51.000000000000000		1	25
Drosophila melanogaster	49.000000000000000		4	12

Showing 1 to 2 of 2 entries

Statistics Data Visualization

minocycline